MORPHOLOGICAL FEATURES OF TUMOR ANGIOGENESIS IN INVASIVE DUCTAL BREAST CANCER

Personalized treatment of patients with invasive ductal breast cancer is one the most pressing issues in modern oncology. Today, information on human genome and molecular markers used to targeted therapy optimize strategies. One abnormal tumor angiogenesis. PECAM-1, or CD31, may be a marker this process. The aim study was comprehensively assess morphological features clinical significance different types tumors microvessels cancer. CD31 expression assessed by positive vascular endothelial staining. Using antibodies (Ab-1, JC70A, Thermo scientific), we investigated 86 cases In histological specimens stained density areas strong vascularization, presence dilated atypical capillaries intratumoral peritumoral stroma, structures local lining were assessed. number capillaries, as well partial estimated semi-quantitative method. According results our study, showed some differences severity No microvascular found depending age patients, T N stages. At same time, higher values stroma noted at G3 degree differentiation, triple-negative HER2/neu positive. significant from prognostic point view vessels lining, characteristic porous loose softly fibrous unformed connective tissue stroma. Angiogenesis, morphology important for value can predict course